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2021-2022 Football
| Date | | Opponent | Location | Result | | W/L |
|---|
| Thu, Sep 02
| | UT Martin | HOUCHENS-SMITH STADI | 59-21 | Story | W |
| UT Martin | HOUCHENS-SMITH STADI | Story | |
| Sat, Sep 11
| | Army | West Point, NY | 35-38 | Story | L |
| Army | West Point, NY | Story | |
| Sat, Sep 25
| | #11 Indiana | HOUCHENS-SMITH STADI | 31-33 | Story | L |
| #11 Indiana | HOUCHENS-SMITH STADI | Story | |
| Sat, Oct 02
| | Michigan State | East Lansing, MI | 31-48 | Story | L |
| Michigan State | East Lansing, MI | Story | |
| Sat, Oct 09
| 6:00 p.m. CT | UTSA | HOUCHENS-SMITH STADI | | | |
| UTSA | HOUCHENS-SMITH STADI | | |
| Sat, Oct 16
| 2:30 p.m. CT | Old Dominion | Norfolk, VA | | | |
| Old Dominion | Norfolk, VA | | |
| Sat, Oct 23
| 6:00 p.m. CT | FIU | Miami, FL | | | |
| FIU | Miami, FL | | |
| Sat, Oct 30
| 3:00 p.m. CT | Charlotte (Homecoming) | HOUCHENS-SMITH STADI | | | |
| Charlotte (Homecoming) | HOUCHENS-SMITH STADI | | |
| Sat, Nov 06
| 2:30 p.m. CT | MTSU | HOUCHENS-SMITH STADI | | | |
| MTSU | HOUCHENS-SMITH STADI | | |
| Sat, Nov 13
| 1:00 p.m. CT | Rice | Houston, TX | | | |
| Rice | Houston, TX | | |
| Sat, Nov 20
| 11:00 a.m. CT | FAU | HOUCHENS-SMITH STADI | | | |
| FAU | HOUCHENS-SMITH STADI | | |
| Sat, Nov 27
| 2:30 p.m. CT | Marshall | Huntington, WV | | | |
| Marshall | Huntington, WV | | |
